CD79a

Il complesso alfa-immunoglobulina associato, noto anche con l'acronimo CD79a (cluster di differenziazione 79A), è una sequenza genica umana associata all'agammaglobulinemia-3^[1].

Il recettore per l'antigene dei linfociti B risulta costituito da un complesso multimerico il quale include il complesso di riconoscimento antigene-specifico di superficie (posizionato sulla membrana cellulare) delle immunoglobuline (Ig); Ed il complesso di superficie delle Ig non-covalenti associati ad altre due proteine: le Ig-alfa (IgA) e le Ig-beta (IgB), le quali sono necessarie per l'espressione ed il funzionamento del recettore per l'antigene delle cellule B. Questo gene (CD79a) codifica per la proteina alfa-Ig appartenente alla componente antigenica delle cellule B. Le isoforme di tale recettore ottenute tramite splicing alternativo della sequenza di trascrizione permettono la codifica di diverse varianti di tale recettore^[1].

Interazioni

Diversi studi hanno dismostrato che il CD79a è in grado di interagire con le cellule B linker^[2]^[3] e con le Alpha-1-microglobulin/bikunin.^[4]^[5]

Note

^ ^a ^b Entrez Gene: CD79A CD79a molecule, immunoglobulin-associated alpha, su ncbi.nlm.nih.gov.
^ N Engels, Wollscheid B, Wienands J, <2126::AID-IMMU2126>3.0.CO;2-O Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha, in Eur. J. Immunol., vol. 31, n. 7, Germany, luglio 2001, pp. 2126–34, DOI:10.1002/1521-4141(200107)31:7<2126::AID-IMMU2126>3.0.CO;2-O, ISSN 0014-2980 (WC · ACNP), PMID 11449366.
^ Shara Kabak, Skaggs Brian J, Gold Michael R, Affolter Michael, West Kelly L, Foster Mark S, Siemasko Karyn, Chan Andrew C, Aebersold Ruedi, Clark Marcus R, The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways, in Mol. Cell. Biol., vol. 22, n. 8, United States, aprile 2002, pp. 2524–35, DOI:10.1128/MCB.22.8.2524-2535.2002, ISSN 0270-7306 (WC · ACNP), PMC 133735, PMID 11909947.
^ A O Grubb, López C, Tejler L, Mendez E, Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration, in J. Biol. Chem., vol. 258, n. 23, UNITED STATES, dicembre 1983, pp. 14698–707, ISSN 0021-9258 (WC · ACNP), PMID 6196366.
^ T Berggård, Thelin N, Falkenberg C, Enghild J J, Akerström B, Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma, in Eur. J. Biochem., vol. 245, n. 3, GERMANY, maggio. 1997, pp. 676–83, DOI:10.1111/j.1432-1033.1997.00676.x, ISSN 0014-2956 (WC · ACNP), PMID 9183005.

Bibliografia

Reth M, Antigen receptors on B lymphocytes., in Annu. Rev. Immunol., vol. 10, 1992, pp. 97–121, DOI:10.1146/annurev.iy.10.040192.000525, PMID 1591006.
Herren B, Burrows PD, B cell-restricted human mb-1 gene: expression, function, and lineage infidelity., in Immunol. Res., vol. 26, n. 1-3, 2003, pp. 35–43, DOI:10.1385/IR:26:1-3:035, PMID 12403343.
Bastian A, Kratzin H, Eckart K, Hilschmann N, Intra- and interchain disulfide bridges of the human J chain in secretory immunoglobulin A., in Biol. Chem. Hoppe-Seyler, vol. 373, n. 12, 1993, pp. 1255–63, PMID 1292512.
Leduc I, Preud'homme JL, Cogné M, Structure and expression of the mb-1 transcript in human lymphoid cells., in Clin. Exp. Immunol., vol. 90, n. 1, 1992, pp. 141–6, DOI:10.1111/j.1365-2249.1992.tb05846.x, PMC 1554548, PMID 1395095.
Kristensen T, Lopez R, Prydz H, An estimate of the sequencing error frequency in the DNA sequence databases., in DNA Seq., vol. 2, n. 6, 1992, pp. 343–6, DOI:10.3109/10425179209020815, PMID 1446073.
Müller B, Cooper L, Terhorst C, Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29., in Eur. J. Immunol., vol. 22, n. 6, 1992, pp. 1621–5, DOI:10.1002/eji.1830220641, PMID 1534761.
Ha HJ, Kubagawa H, Burrows PD, Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene., in J. Immunol., vol. 148, n. 5, 1992, pp. 1526–31, PMID 1538135.
Hutchcroft JE, Harrison ML, Geahlen RL, Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor., in J. Biol. Chem., vol. 267, n. 12, 1992, pp. 8613–9, PMID 1569106.
Flaswinkel H, Reth M, Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex., in Immunogenetics, vol. 36, n. 4, 1992, pp. 266–9, DOI:10.1007/BF00215058, PMID 1639443.
Yu LM, Chang TW, Human mb-1 gene: complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes., in J. Immunol., vol. 148, n. 2, 1992, pp. 633–7, PMID 1729378.
Venkitaraman AR, Williams GT, Dariavach P, Neuberger MS, The B-cell antigen receptor of the five immunoglobulin classes., in Nature, vol. 352, n. 6338, 1991, pp. 777–81, DOI:10.1038/352777a0, PMID 1881434.
Bakos MA, Kurosky A, Goldblum RM, Characterization of a critical binding site for human polymeric Ig on secretory component., in J. Immunol., vol. 147, n. 10, 1991, pp. 3419–26, PMID 1940346.
Sakaguchi N, Kashiwamura S, Kimoto M, et al., B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties., in EMBO J., vol. 7, n. 11, 1989, pp. 3457–64, PMC 454845, PMID 2463161.
Grubb AO, López C, Tejler L, Mendez E, Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration., in J. Biol. Chem., vol. 258, n. 23, 1984, pp. 14698–707, PMID 6196366.
Kurosaki T, Johnson SA, Pao L, et al., Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling., in J. Exp. Med., vol. 182, n. 6, 1996, pp. 1815–23, DOI:10.1084/jem.182.6.1815, PMC 2192262, PMID 7500027.
Lankester AC, van Schijndel GM, Cordell JL, et al., CD5 is associated with the human B cell antigen receptor complex., in Eur. J. Immunol., vol. 24, n. 4, 1994, pp. 812–6, DOI:10.1002/eji.1830240406, PMID 7512031.
Vasile S, Coligan JE, Yoshida M, Seon BK, Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex., in Mol. Immunol., vol. 31, n. 6, 1994, pp. 419–27, DOI:10.1016/0161-5890(94)90061-2, PMID 7514267.
Brown VK, Ogle EW, Burkhardt AL, et al., Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45., in J. Biol. Chem., vol. 269, n. 25, 1994, pp. 17238–44, PMID 7516335.
Pani G, Kozlowski M, Cambier JC, et al., Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling., in J. Exp. Med., vol. 181, n. 6, 1995, pp. 2077–84, DOI:10.1084/jem.181.6.2077, PMC 2192043, PMID 7539038.

Collegamenti esterni

(EN) CD79A protein, human, in Medical Subject Headings (MeSH), National Library of Medicine, 2009.

Portale Biologia: accedi alle voci di Wikipedia che trattano di Biologia

[entrez-1] Entrez Gene: CD79A CD79a molecule, immunoglobulin-associated alpha, su ncbi.nlm.nih.gov.

[pmid11449366-2] N Engels, Wollscheid B, Wienands J, <2126::AID-IMMU2126>3.0.CO;2-O Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha, in Eur. J. Immunol., vol. 31, n. 7, Germany, luglio 2001, pp. 2126–34, DOI:10.1002/1521-4141(200107)31:7<2126::AID-IMMU2126>3.0.CO;2-O, ISSN 0014-2980 (WC · ACNP), PMID 11449366.

[pmid11909947-3] Shara Kabak, Skaggs Brian J, Gold Michael R, Affolter Michael, West Kelly L, Foster Mark S, Siemasko Karyn, Chan Andrew C, Aebersold Ruedi, Clark Marcus R, The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways, in Mol. Cell. Biol., vol. 22, n. 8, United States, aprile 2002, pp. 2524–35, DOI:10.1128/MCB.22.8.2524-2535.2002, ISSN 0270-7306 (WC · ACNP), PMC 133735, PMID 11909947.

[pmid6196366-4] A O Grubb, López C, Tejler L, Mendez E, Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration, in J. Biol. Chem., vol. 258, n. 23, UNITED STATES, dicembre 1983, pp. 14698–707, ISSN 0021-9258 (WC · ACNP), PMID 6196366.

[pmid9183005-5] T Berggård, Thelin N, Falkenberg C, Enghild J J, Akerström B, Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma, in Eur. J. Biochem., vol. 245, n. 3, GERMANY, maggio. 1997, pp. 676–83, DOI:10.1111/j.1432-1033.1997.00676.x, ISSN 0014-2956 (WC · ACNP), PMID 9183005.

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