Granzima M
gene umano
Il granzima M è una proteina che negli umani viene codificata dal gene GZMM;[1][2] essa fa parte della categoria dei granzimi.
| Granzima M | |
|---|---|
 | |
| Gene | |
| Entrez | 3004 |
| Locus | Chr. 19 p13.3 |
| Proteina | |
| OMIM | 600311 |
Il gene GZMM è situato sul braccio corto del cromosoma 19, nel locus genico 19p13.3.[3]
Note
modifica- ^ (EN) Baker E, Sutherland GR, Smyth MJ, The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3, in Immunogenetics, vol. 39, n. 4, aprile 1994, pp. 294-295, DOI:10.1007/bf00188796, PMID 8119738.
- ^ (EN) GZMM Granzyme M (lymphocyte met-ase 1), su Entrez Gene. URL consultato il 6 aprile 2023.
- ^ (EN) GRCh38: Ensembl release 89: ENSG00000197540, su Ensembl. URL consultato il 6 aprile 2023.
Bibliografia
modifica- (EN) Smyth MJ, O'Connor MD, Trapani JA, Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies, in J. Leukoc. Biol., vol. 60, n. 5, 1996, pp. 555–562, DOI:10.1002/jlb.60.5.555, PMID 8929545.
- (EN) Pilat D, Fink T, Obermaier-Skrobanek B et al., The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3, in Genomics, vol. 24, n. 3, 1995, pp. 445–450, DOI:10.1006/geno.1994.1651, PMID 7713495.
- Smyth MJ, Sayers TJ, Wiltrout T et al., Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells., in Journal of Immunology, vol. 151, n. 11, 1994, pp. 6195–6205, PMID 8245461.
- (EN) Strausberg RL, Feingold EA, Grouse LH et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., in Proc. Natl. Acad. Sci. U.S.A., vol. 99, n. 26, 2003, pp. 16899–16903, DOI:10.1073/pnas.242603899, PMID 12477932.
- (EN) Krenacs L, Smyth MJ, Bagdi E et al., The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity, in Blood, vol. 101, n. 9, 2003, pp. 3590–3593, DOI:10.1182/blood-2002-09-2908, PMID 12506019.
- (EN) Kelly JM, Waterhouse NJ, Cretney E et al., Granzyme M mediates a novel form of perforin-dependent cell death, in J. Biol. Chem., vol. 279, n. 21, 2004, pp. 22236–22242, DOI:10.1074/jbc.M401670200, PMID 15028722.
- (EN) Gerhard DS, Wagner L, Feingold EA et al., The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC), in Genome Res., vol. 14, 10B, 2004, pp. 2121–2127, DOI:10.1101/gr.2596504, PMID 15489334.
- (EN) Mahrus S, Kisiel W, Craik CS, Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B, in J. Biol. Chem., vol. 279, n. 52, 2005, pp. 54275–54282, DOI:10.1074/jbc.M411482200, PMID 15494398.
- (EN) Lu H, Hou Q, Zhao T et al., Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation, in Journal of Immunology, vol. 177, n. 2, 2006, pp. 1171–1178, DOI:10.4049/jimmunol.177.2.1171, PMID 16818775.