N1,N12-diacetilspermina
farmaco
La N1,N12-diacetilspermina (DiAcSpm) è una poliammina. L'enzima N1-acetilpoliammino ossidasi (numero EC 1.5.3.13[1]) ne catalizza l'ossidazione con formazione di N1-acetilspermidina e H2O2.
| N1,N12-diacetilspermina | |
|---|---|
,N(12)-Diacetylspermine.png) | |
| Caratteristiche generali | |
| Formula bruta o molecolare | C14H30N4O2 |
| Massa molecolare (u) | 286,4136 |
| Numero CAS | |
| PubChem | 132680 |
| SMILES | CC(=O)NCCCNCCCCNCCCNC(=O)C |
| Indicazioni di sicurezza | |
Note
modificaBibliografia
modifica- (EN) K. Hiramatsu, M. Sugimoto, S. Kamei, M. Hoshino, K. Kinoshita, K. Iwasaki and M. Kawakita, Determination of Amounts of Polyamines Excreted in Urine: Demonstration of N1,N8-Diacetylspermidine and N1,N12-Diacetylspermine as Components Commonly Occurring in Normal Human Urine, in J Biochem, vol. 117, n. 1, 1995, pp. 107-112.
- (EN) K. Hiramatsu et al., N1,N12-Diacetylspermine as a Sensitive and Specific Novel Marker for Early- and Late-Stage Colorectal and Breast Cancers, in Clinical Cancer Research, vol. 11, n. 8, 2005, pp. 2986–2990, DOI:10.1158/1078-0432.CCR-04-2275.
- (EN) Masao Kawakita and Kyoko Hiramatsu, Diacetylated Derivatives of Spermine and Spermidine as Novel Promising Tumor Markers, in Journal of Biochemistry, vol. 139, n. 3, 2006, pp. 315–322, DOI:10.1093/jb/mvj068.
