RANK
RANK (dall'acronimo in lingua inglese per Receptor Activator of Nuclear Factor κ B), anche chiamato recettore del fattore di necrosi tumorale 11A o recettore TRANCE, è una proteina recettoriale che, nell'essere umano, è codificata dal gene TNFRSF11A e fa parte della superfamiglia dei recettori del fattore di necrosi tumorale[1].
| Recettore del fattore di necrosi tissutale 11A | |
|---|---|
| Gene | |
| HUGO | TNFRSF11A CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TRANCER |
| Locus | Chr. 18 q21.33 |
| Proteina | |
| UniProt | Q9Y6Q6 |
Struttura e funzione
modificaSi tratta di una proteina di membrana di tipo I espressa sulla superficie degli osteoclasti ed è coinvolto nella loro attivazione mediante il legame con RANKL, che si ritrova sulla membrana delle cellule stromali, degli osteoblasti e dei linfociti T. RANK può essere espressa anche dalle cellule dentritiche, dove facilita la trasduzione del segnale regolatrice la risposta immunitaria[1][2][3].
Interazioni
modificaRANK interagisce con numerosi membri della famiglia TRAF, in particolar modo con TRAF6[4][5][6][7][8], TRAF5[5][6][7], TRAF1[7][8], TRAF2[5][6][7][8] e TRAF3[7][8].
Note
modifica- ^ a b Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ, Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families, in Endocr. Rev., vol. 20, n. 3, 1999, pp. 345–57, DOI:10.1210/er.20.3.345, PMID 10368775.
- ^ Wong BR, Josien R, Choi Y, TRANCE is a TNF family member that regulates dendritic cell and osteoclast function, in J. Leukoc. Biol., vol. 65, n. 6, 1999, pp. 715–24, PMID 10380891 (archiviato dall'url originale il 19 aprile 2008).
- ^ Theill LE, Boyle WJ, Penninger JM, RANK-L and RANK: T cells, bone loss, and mammalian evolution, in Annu. Rev. Immunol., vol. 20, 2002, pp. 795–823, DOI:10.1146/annurev.immunol.20.100301.064753, PMID 11861618.
- ^ Junko Mizukami, Takaesu Giichi, Akatsuka Hiroyuki, Sakurai Hiroaki, Ninomiya-Tsuji Jun, Matsumoto Kunihiro, Sakurai Naoki, Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6, in Mol. Cell. Biol., vol. 22, n. 4, United States, febbraio 2002, pp. 992–1000, DOI:10.1128/MCB.22.4.992-1000.2002, ISSN 0270-7306, PMC 134634, PMID 11809792.
- ^ a b c B G Darnay, Haridas V, Ni J, Moore P A, Aggarwal B B, Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase, in J. Biol. Chem., vol. 273, n. 32, UNITED STATES, agosto 1998, pp. 20551–5, DOI:10.1074/jbc.273.32.20551, ISSN 0021-9258, PMID 9685412.
- ^ a b c B G Darnay, Ni J, Moore P A, Aggarwal B B, Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif, in J. Biol. Chem., vol. 274, n. 12, UNITED STATES, marzo 1999, pp. 7724–31, DOI:10.1074/jbc.274.12.7724, ISSN 0021-9258, PMID 10075662.
- ^ a b c d e L Galibert, Tometsko M E, Anderson D M, Cosman D, Dougall W C, The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily, in J. Biol. Chem., vol. 273, n. 51, UNITED STATES, dicembre 1998, pp. 34120–7, DOI:10.1074/jbc.273.51.34120, ISSN 0021-9258, PMID 9852070.
- ^ a b c d H H Kim, Lee D E, Shin J N, Lee Y S, Jeon Y M, Chung C H, Ni J, Kwon B S, Lee Z H, Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase, in FEBS Lett., vol. 443, n. 3, NETHERLANDS, Jan. 1999, pp. 297–302, DOI:10.1016/S0014-5793(98)01731-1, ISSN 0014-5793, PMID 10025951.
Bibliografia
modifica- Romas E, Gillespie MT, Martin TJ, Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis., in Bone, vol. 30, n. 2, 2002, pp. 340–6, DOI:10.1016/S8756-3282(01)00682-2, PMID 11856640.
- Collin-Osdoby P, Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin., in Circ. Res., vol. 95, n. 11, 2005, pp. 1046–57, DOI:10.1161/01.RES.0000149165.99974.12, PMID 15564564.
- Clohisy DR, Mantyh PW, Bone cancer pain and the role of RANKL/OPG., in Journal of musculoskeletal & neuronal interactions, vol. 4, n. 3, 2005, pp. 293–300, PMID 15615497.
- Anandarajah AP, Schwarz EM, Anti-RANKL therapy for inflammatory bone disorders: Mechanisms and potential clinical applications., in J. Cell. Biochem., vol. 97, n. 2, 2006, pp. 226–32, DOI:10.1002/jcb.20674, PMID 16240334.
- Baud'huin M, Duplomb L, Ruiz Velasco C, et al., Key roles of the OPG-RANK-RANKL system in bone oncology., in Expert Rev Anticancer Ther, vol. 7, n. 2, 2007, pp. 221–32, DOI:10.1586/14737140.7.2.221, PMID 17288531.
- Boyce BF, Xing L, Biology of RANK, RANKL, and osteoprotegerin., in Arthritis Res. Ther., 9 Suppl 1, 2007, pp. S1, DOI:10.1186/ar2165, PMC 1924516, PMID 17634140.
- Hughes AE, Shearman AM, Weber JL, et al., Genetic linkage of familial expansile osteolysis to chromosome 18q., in Hum. Mol. Genet., vol. 3, n. 2, 1994, pp. 359–61, DOI:10.1093/hmg/3.2.359, PMID 7911698.
- Cody JD, Singer FR, Roodman GD, et al., Genetic linkage of Paget disease of the bone to chromosome 18q., in Am. J. Hum. Genet., vol. 61, n. 5, 1997, pp. 1117–22, DOI:10.1086/301601, PMC 1716035, PMID 9345096.
- Anderson DM, Maraskovsky E, Billingsley WL, et al., A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function., in Nature, vol. 390, n. 6656, 1997, pp. 175–9, DOI:10.1038/36593, PMID 9367155.
- Haslam SI, Van Hul W, Morales-Piga A, et al., Paget's disease of bone: evidence for a susceptibility locus on chromosome 18q and for genetic heterogeneity., in J. Bone Miner. Res., vol. 13, n. 6, 1998, pp. 911–7, DOI:10.1359/jbmr.1998.13.6.911, PMID 9626621.
- Darnay BG, Haridas V, Ni J, et al., Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase., in J. Biol. Chem., vol. 273, n. 32, 1998, pp. 20551–5, DOI:10.1074/jbc.273.32.20551, PMID 9685412.
- Wong BR, Josien R, Lee SY, et al., The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor., in J. Biol. Chem., vol. 273, n. 43, 1998, pp. 28355–9, DOI:10.1074/jbc.273.43.28355, PMID 9774460.
- Galibert L, Tometsko ME, Anderson DM, et al., The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily., in J. Biol. Chem., vol. 273, n. 51, 1999, pp. 34120–7, DOI:10.1074/jbc.273.51.34120, PMID 9852070.
- Nakagawa N, Kinosaki M, Yamaguchi K, et al., RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis., in Biochem. Biophys. Res. Commun., vol. 253, n. 2, 1999, pp. 395–400, DOI:10.1006/bbrc.1998.9788, PMID 9878548.
- Kim HH, Lee DE, Shin JN, et al., Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase., in FEBS Lett., vol. 443, n. 3, 1999, pp. 297–302, DOI:10.1016/S0014-5793(98)01731-1, PMID 10025951.
- Darnay BG, Ni J, Moore PA, Aggarwal BB, Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif., in J. Biol. Chem., vol. 274, n. 12, 1999, pp. 7724–31, DOI:10.1074/jbc.274.12.7724, PMID 10075662.
- Hsu H, Lacey DL, Dunstan CR, et al., Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand., in Proc. Natl. Acad. Sci. U.S.A., vol. 96, n. 7, 1999, pp. 3540–5, DOI:10.1073/pnas.96.7.3540, PMC 22329, PMID 10097072.
- Dougall WC, Glaccum M, Charrier K, et al., RANK is essential for osteoclast and lymph node development., in Genes Dev., vol. 13, n. 18, 1999, pp. 2412–24, DOI:10.1101/gad.13.18.2412, PMC 317030, PMID 10500098.
- Hughes AE, Ralston SH, Marken J, et al., Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis., in Nat. Genet., vol. 24, n. 1, 2000, pp. 45–8, DOI:10.1038/71667, PMID 10615125.
- Wong BR, Besser D, Kim N, et al., TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src., in Mol. Cell, vol. 4, n. 6, 2000, pp. 1041–9, DOI:10.1016/S1097-2765(00)80232-4, PMID 10635328.
