Fattore di crescita trasformante alfa

Il fattore di crescita trasformante alfa (TGF-α, Transforming growth factor alpha in inglese) è un fattore di crescita prodotto dai macrofagi, dalle cellule cerebrali e dai cheratinociti. Tale fattore di crescita risulta iperespresso in alcune neoplasie umane.

Il TGF-α provoca lo sviluppo dell'epitelio ed è strettamente legato al fattore di crescita epidermale (EGF). Si può legare al recettore del fattore di crescita epidermale (EGFR) con effetti simili. Stimola anche la proliferazione delle cellule neuronali nel cervello adulto leso.^[1]

Il TGF-α è stato citato nel rapporto al Congresso degli Stati Uniti dei National Institutes of Health sulle cellule staminali del 2001 come una dimostrazione promettente dell'abilità delle cellule staminali adulte di ripristinare la funzionalità nelle malattie neurodegenerative.^[2]

Interazioni

È stato dimostrato che il fattore di crescita trasformante alfa interagisce con GORASP1 e GORASP2.^[3]

Note

^ Fallon J, Reid S, Kinyamu R, Opole I, Opole R, Baratta J, Korc M, Endo TL, Duong A, Nguyen G, Karkehabadhi M, Twardzik D, Patel S, Loughlin S, In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain, in Proc Natl Acad Sci USA, vol. 97, n. 26, 19 dicembre 2000, pp. 14686-91, PMID 11121069.
^ National Institutes of Health, Stem Cells: Scientific Progress and Future Research Directions, giugno 2001 (archiviato dall'url originale il 25 maggio 2010).
^ FA Barr, Preisinger C, Kopajtich R, Körner R, Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus, in J. Cell Biol., vol. 155, n. 6, dicembre 2001, pp. 885-91, DOI:10.1083/jcb.200108102, PMID 11739402.

Bibliografia

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Greten FR, Wagner M, Weber CK, et al., TGF alpha transgenic mice. A model of pancreatic cancer development, in Pancreatology, vol. 1, n. 4, 2002, pp. 363–8, DOI:10.1159/000055835, PMID 12120215.
Vieira AR, Association between the transforming growth factor alpha gene and nonsyndromic oral clefts: a HuGE review (PDF), in Am. J. Epidemiol., vol. 163, n. 9, 2006, pp. 790–810, DOI:10.1093/aje/kwj103, PMID 16495466.
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Werner S, Roth WK, Bates B, et al., Fibroblast growth factor 5 proto-oncogene is expressed in normal human fibroblasts and induced by serum growth factors, in Oncogene, vol. 6, n. 11, 1991, pp. 2137–44, PMID 1658709.
Saeki T, Cristiano A, Lynch MJ, et al., Regulation by estrogen through the 5'-flanking region of the transforming growth factor alpha gene, in Mol. Endocrinol., vol. 5, n. 12, 1992, pp. 1955–63, DOI:10.1210/mend-5-12-1955, PMID 1791840.
Harvey TS, Wilkinson AJ, Tappin MJ, et al., The solution structure of human transforming growth factor alpha ^{[collegamento interrotto]}, in Eur. J. Biochem., vol. 198, n. 3, 1991, pp. 555–62, DOI:10.1111/j.1432-1033.1991.tb16050.x, PMID 2050136.
Kline TP, Brown FK, Brown SC, et al., Solution structures of human transforming growth factor alpha derived from 1H NMR data, in Biochemistry, vol. 29, n. 34, 1991, pp. 7805–13, DOI:10.1021/bi00486a005, PMID 2261437.
Jakowlew SB, Kondaiah P, Dillard PJ, et al., A novel low molecular weight ribonucleic acid (RNA) related to transforming growth factor alpha messenger RNA, in Mol. Endocrinol., vol. 2, n. 11, 1989, pp. 1056–63, DOI:10.1210/mend-2-11-1056, PMID 2464748.
Jakobovits EB, Schlokat U, Vannice JL, et al., The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence (PDF), in Mol. Cell. Biol., vol. 8, n. 12, 1989, pp. 5549–54, DOI:10.0270-7306/88/125549-06$02.00/0, PMID 2907605.
Tricoli JV, Nakai H, Byers MG, et al., The gene for human transforming growth factor alpha is on the short arm of chromosome 2, in Cytogenet. Cell Genet., vol. 42, n. 1-2, 1986, pp. 94–8, DOI:10.1159/000132258, PMID 3459638.
Lee DC, Rose TM, Webb NR, Todaro GJ, Cloning and sequence analysis of a cDNA for rat transforming growth factor-alpha, in Nature, vol. 313, n. 6002, 1985, pp. 489–91, DOI:10.1038/313489a0, PMID 3855503.
Derynck R, Roberts AB, Winkler ME, et al., Human transforming growth factor-alpha: precursor structure and expression in E. coli, in Cell, vol. 38, n. 1, 1984, pp. 287–97, DOI:10.1016/0092-8674(84)90550-6, PMID 6088071.
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Walz TM, Malm C, Nishikawa BK, Wasteson A, Transforming growth factor-alpha (TGF-alpha) in human bone marrow: demonstration of TGF-alpha in erythroblasts and eosinophilic precursor cells and of epidermal growth factor receptors in blastlike cells of myelomonocytic origin, in Blood, vol. 85, n. 9, 1995, pp. 2385–92, PMID 7727772.
Patel B, Hiscott P, Charteris D, et al., Retinal and preretinal localisation of epidermal growth factor, transforming growth factor alpha, and their receptor in proliferative diabetic retinopathy, in The British journal of ophthalmology, vol. 78, n. 9, 1994, pp. 714–8, DOI:10.1136/bjo.78.9.714, PMID 7947554.

Collegamenti esterni

(EN) MeSH Transforming Growht Factor alpha

Portale Biologia

Portale Medicina

[1] Fallon J, Reid S, Kinyamu R, Opole I, Opole R, Baratta J, Korc M, Endo TL, Duong A, Nguyen G, Karkehabadhi M, Twardzik D, Patel S, Loughlin S, In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain, in Proc Natl Acad Sci USA, vol. 97, n. 26, 19 dicembre 2000, pp. 14686-91, PMID 11121069.

[2] National Institutes of Health, Stem Cells: Scientific Progress and Future Research Directions, giugno 2001 (archiviato dall'url originale il 25 maggio 2010).

[pmid11739402-3] FA Barr, Preisinger C, Kopajtich R, Körner R, Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus, in J. Cell Biol., vol. 155, n. 6, dicembre 2001, pp. 885-91, DOI:10.1083/jcb.200108102, PMID 11739402.

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