Parametasone
composto chimico
Il Parametasone è un glucocorticoide fluorinato-alogenato dalle proprietà antiinfiammatorie e immunodepressive.[1]
| Isoflupredone | |
|---|---|
 | |
| Nome IUPAC | |
| (6α,11β,16α)-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione | |
| Nomi alternativi | |
| (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one | |
| Caratteristiche generali | |
| Formula bruta o molecolare | C22H29FO5 |
| Massa molecolare (u) | 392,467 g/mol-1 |
| Numero CAS | |
| Numero EINECS | 200-169-2 |
| PubChem | 5875 |
| DrugBank | DBDB01384 |
| SMILES | CC1CC2C3CC(C4=CC(=O)C=CC4(C3C(CC2(C1(C(=O)CO)O)C)O)C)F |
| Indicazioni di sicurezza | |
Note
modifica- ^ Toxnet: Paramethasone Archiviato il 29 agosto 2019 in Internet Archive.
Bibliografia
modifica- Wershil BK, Furuta GT, Lavigne JA, Choudhury AR, Wang ZS, Galli SJ, Dexamethasone and cyclosporin A suppress mast cell-leukocyte cytokine cascades by multiple mechanisms, in International Archives of Allergy and Immunology, vol. 107, 1–3, 1995, pp. 323–4, DOI:10.1159/000237015, PMID 7613160.
- Riccardi C, Cifone MG, Migliorati G, Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes, in Cell Death and Differentiation, vol. 6, n. 12, dicembre 1999, pp. 1182–9, DOI:10.1038/sj.cdd.4400609, PMID 10637434.
- Lavista Llanos S, Roldán A, Effect of dexamethasone on nitric oxide (NO.) production by cultured astrocytes, in Biocell, vol. 23, n. 1, aprile 1999, pp. 29–35, PMID 10904533.