Tirosina-tRNA ligasi
enzima
La tirosina-tRNA ligasi è un enzima, appartenente alla classe delle ligasi, che catalizza la seguente reazione:
| tirosina-tRNA ligasi | |
|---|---|
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| Numero EC | 6.1.1.1 |
| Classe | Ligasi |
| Nome sistematico | |
| L-tirosina:tRNATyr ligasi (forma AMP) | |
| Altri nomi | |
| tirosina-tRNA ligasi | |
| Banche dati | BRENDA, EXPASY, GTD, PDB (RCSB PDB PDBe PDBj PDBsum) |
| Fonte: IUBMB | |
ATP + L-tirosina + tRNATyr = AMP + difosfato + L-tirosil-tRNATyr
Bibliografia
modifica- Allen, E.H., Glassman, E. e Schweet, R.S. Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes. J. Biol. Chem. 235 (1960) 1061–1067. Entrez PubMed 13792726
- Cowles, J.R. e Key, J.L. Demonstration of two tyrosyl-tRNA synthetases of pea roots. Biochim. Biophys. Acta 281 (1972) 33–44. Entrez PubMed 4563531
- Holley, R.W., Brunngraber, E.F., Saad, F. e Williams, H.H. Partial purification of the threonine- and tyrosine-activating enzymes from rat liver, and the effect of potassium ions on the activity of the tyrosine enzyme. J. Biol. Chem. 236 (1961) 197–199. Entrez PubMed 13715350
- Schweet, R.S. e Allen, E.H. Purification and properties of tyrosine-activating enzyme of hog pancreas. J. Biol. Chem. 233 (1958) 1104–1108.
- Brick, P., Bhat, T.N. e Blow, D.M. Structure of tyrosyl-tRNA synthetase refined at 2.3 Å resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate. J. Mol. Biol. 208 (1989) 83–98. Entrez PubMed 2504923
