Recettore della somatostatina 4

Il recettore della somatostatina 4 è una proteina recettoriale codificata nell'uomo dal gene SSTR4.

Recettore della somatostatina 4
Gene
HUGO	SSTR4
Entrez	6754
Locus	Chr. 20 p11.21
Proteina
OMIM	182454
UniProt	P31391

La somatostatina agisce in molti siti recettoriali inibendo il rilascio di ormoni e altre proteine secretorie. Gli effetti biologici sono probabilmente mediati da una famiglia di recettori accoppiati a proteine G espressi in modalità tessuto-specifiche. In particolare SSTR4 fa parte della superfamiglia dei recettori con sette domini transmembrana ed è iperespresso, nel feto e nell'adulto, a livello del cervello e del polmone.

Bibliografia

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• Yamada Y, Kagimoto S, Kubota A, K. Yasuda, K. Masuda, Y. Someya, Y. Ihara, Q. Li e H. Imura, Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype, in Biochem. Biophys. Res. Commun., vol. 195, n. 2, 1993, pp. 844–52, DOI:10.1006/bbrc.1993.2122, PMID 8373420.
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• Fukusumi S, Kitada C, Takekawa S, Hideki Kizawa, Junko Sakamoto, Masaomi Miyamoto, Shuji Hinuma, Kazuaki Kitano e Masahiko Fujino, Identification and characterization of a novel human cortistatin-like peptide, in Biochem. Biophys. Res. Commun., vol. 232, n. 1, 1997, pp. 157–63, DOI:10.1006/bbrc.1997.6252, PMID 9125122.
• de Lecea L, Ruiz-Lozano P, Danielson PE, Jessica Peelle-Kirley, Pamela E. Foye, Wayne N. Frankel e J.Gregor Sutcliffe, Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin, in Genomics, vol. 42, n. 3, 1997, pp. 499–506, DOI:10.1006/geno.1997.4763, PMID 9205124.
• Jaïs P, Terris B, Ruszniewski P, M. Leromancer, F. Reyl-Desmars, C. Vissuzaine, G. Cadiot, M. Mignon e M. J. M. Lewin, Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours, in Eur. J. Clin. Invest., vol. 27, n. 8, 1997, pp. 639–44, DOI:10.1046/j.1365-2362.1997.1740719.x, PMID 9279525.
• Sharma K, Patel YC, Srikant CB, C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest, in Mol. Endocrinol., vol. 13, n. 1, 1999, pp. 82–90, DOI:10.1210/me.13.1.82, PMID 9892014.
• Forssell-Aronsson EB, Nilsson O, Bejegård SA, L Kölby, P Bernhardt, J Mölne, SH Hashemi, B Wängberg e LE Tisell, 111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors, in J. Nucl. Med., vol. 41, n. 4, 2000, pp. 636–42, PMID 10768564.
• Zatelli MC, Tagliati F, Taylor JE, R Rossi, MD Culler e EC Degli Uberti, Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt, in J. Clin. Endocrinol. Metab., vol. 86, n. 5, 2001, pp. 2161–9, DOI:10.1210/jc.86.5.2161, PMID 11344221.
• Talme T, Ivanoff J, Hägglund M, R. J. J. Van Neerven, A. Ivanoff e K. G. Sundqvist, Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3, in Clin. Exp. Immunol., vol. 125, n. 1, 2001, pp. 71–9, DOI:10.1046/j.1365-2249.2001.01577.x, PMC 1906108, PMID 11472428.
• Pasquali D, Notaro A, Esposito D, P Vassallo, G Bonavolontà, A Bellastella e AA Sinisi, [Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy], in Minerva Endocrinol., vol. 26, n. 3, 2002, pp. 175–9, PMID 11753241.
• Deloukas P, Matthews LH, Ashurst J, J. Burton, J. G. R. Gilbert, M. Jones, G. Stavrides, J. P. Almeida e A. K. Babbage, The DNA sequence and comparative analysis of human chromosome 20, in Nature, vol. 414, n. 6866, 2002, pp. 865–71, DOI:10.1038/414865a, PMID 11780052.
• Papotti M, Bongiovanni M, Volante M, Allìa e., Landolfi s., Helboe l., Schindler m., Cole s. e Bussolati g., Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis, in Virchows Arch., vol. 440, n. 5, 2002, pp. 461–75, DOI:10.1007/s00428-002-0609-x, PMID 12021920.

Voci correlate

• Recettore della somatostatina

Collegamenti esterni

• Recettore della somatostatina: sst₄, su IUPHAR Database of Receptors and Ion Channels, International Union of Basic and Clinical Pharmacology (archiviato dall'url originale il 18 settembre 2012).
• Mesh, su nlm.nih.gov.